Rationale for Controlled Continuous Local Delivery of Sirolimus Through Porous ePTFE
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Sirolimus (rapamycin) is an established FDA approved drug with a 20 year history of safety & efficacy
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Sirolimus formulation is stable at body temp
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Infusion can be adjusted, delayed or stopped
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Systemic drug concentrations of sirolimus well below immunosuppressive levels
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Ready antidote: Stop or remove drug pump leaving a largely unaffected ePTFE graft
