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Rationale of Local Sirolimus Delivery

  • Sirolimus is a cytostatic drug that arrests cells mid-cycle but does not kill cells

  • Sirolimus is as an anti-proliferative agent that prevents neointima formation.

Rationale for sirolimus local delivery

  • Retard neointimal cell proliferation

  • Prevent obstruction of the graft

  • Extend graft utility and function