Proof of Concept

  • Local sirolimus (rapamycin) infusion for 30 days in non-human primates with implanted ePTFE rats elicited a dramatic 80% reduction in vessel thickening at one month.

  • Termination of the sirolimus infusion at 30 days led to rapid reformation of the stenotic lesion at 90 days, indicating continual drug administration is required.  

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