Cylerus was created to focus on the problems associated with creating long term successful vascular access for hemodialysis patients with end stage renal disease (ESRD).  The Cylerus solution couples the  antiproliferative properties of sirolimus in a body

temperature stable formulation, with an implantable proprietary  mechanical pump and drug eluting cuff (DEC) that delivers locally, therapeutic levels of sirolimus (rapamycin) with little impact on systemic levels of the drug.